When screening private label single dose skincare manufacturers for brand clients, production filling lines are my top priority rather than formulations. The BFS (Blow-Fill-Seal) integrated technology originated from sterile filling processes in the German pharmaceutical industry back in the 1960s. Featuring individually sealed single units for instant use, it fundamentally prevents oxidation of active ingredients and secondary contamination. Nevertheless, only a handful of cosmetic manufacturers worldwide can operate this production line stably. Below are seven benchmark manufacturers I have shortlisted.
Quick Comparison Chart
| Manufacturer Name | Country / Region | Core Advantages | Key Certifications |
| Gilbert Group | France | World’s second-largest sterile single-dose manufacturer with 15 BFS machines and an annual output of over 1 billion units | GMP，ISO 22716，ECOCERT |
| Desifine | China | Sino-German joint venture, featuring BFS sterile filling and 8-Free clean formulations | ISO 22716 certified, FDA registered |
| Neftis Laboratorios | Spain | One of Europe’s first ISO 22716-certified single-dose cosmetic manufacturers, providing full product formats: BFS sachets, glass ampoules and cosmetic syringes | ISO 22716，ISO 13485 |
| Phytocosma | France | France’s largest glass ampoule serum manufacturer, founded in 1982 | ISO 22716 |
| Cosmecca Korea | South Korea | KOSDAQ-listed OGM, full-category single-dose manufacturing | CGMP，ISO 22716，FDA OTC |
| Crevil | Germany | GMP and ISO 22716 certified CDMO, pharmaceutical-grade skincare manufacturing | GMP，ISO 22716（DIN EN） |
| Briemar | Australia | TGA certified, over 50 years of contract sachet manufacturing, pharmaceutical-grade standards | ISO 22716，ISO 13485，TGA |
1.Gilbert Group
Founded in 1904, Gilbert Group is a French family-owned pharmaceutical conglomerate and the world’s second-largest manufacturer of sterile single-dose products. The group operates six production sites across France equipped with multiple Blow-Fill-Seal (BFS) machines, churning out over 1 billion sterile single-dose units annually. Its CDMO business spans pharmaceuticals, medical devices and cosmetics, serving more than 200 brands worldwide. It delivers one-stop pharmaceutical-grade contract manufacturing services for private label single dose skincare, covering everything from formula development to sterile filling. In 2023, the group posted revenue exceeding 230 million euros with a workforce of over 1,000 employees.
Factory Profile
- Established in 1904; six French manufacturing facilities located in Normandy and Brittany, with multiple BFS production lines
- Certifications including GMP, ISO 22716 and ECOCERT; annual output of over 1 billion sterile single-dose formulations
Core Expertise
- World’s second-largest BFS production capacity: Adopts pharmaceutical-grade sterile filling standards, ideal for sensitive skin and medical-grade skincare
- ECOCERT organic certification: Supports the development of single-dose products formulated to meet COSMOS organic standards
2.Desifine
Desifine is a Sino-German joint venture cosmetic OEM/ODM manufacturer. Its R&D team is led by Dr. Rolf Lentfer, a former senior engineer from Henkel. The private label single dose skincare production lines adopt integrated Blow-Fill-Seal (BFS) technology paired with an 8-Free clean formula system, with single-unit sealed filling completed in Class 100,000 cleanrooms. The factory holds dual qualifications of ISO 22716 certification and FDA registration, with 80% of its products exported to European and American markets.
Factory Profile
- Founded in 2000; 15,000 ㎡ garden-style factory with 6 automated production lines; raw materials sourced from BASF, Symrise and Dow
- ISO 22716 certified & FDA registered; BFS sterile filling plus low-temperature filling to safeguard heat-sensitive active ingredients
Core Expertise
- BFS single-dose active ingredient preservation: Low-temperature filling and preservative-free formulas, compatible with oxidation-prone ingredients such as Vitamin C and Copper Peptides
- 80% export volume to Europe and the US; proficient in EU regulatory documentation including CPNP and CPSR, as well as FDA compliance requirements
3.Neftis Laboratorios
Founded in Barcelona in 2005, Neftis Laboratorios is one of Europe’s first CDMOs for private label single dose skincare certified with ISO 22716. Its 7,000-square-meter factory covers the full workflow from formula development to aseptic filling. Its product range includes ampoules, serums, creams and mesotherapy products. It supports custom formulation development or fast product launches with ready-made formulas, with goods exported to East Asia, Europe, the Middle East and South America.
Factory Profile
- Established in 2005; self-owned 7,000 ㎡ factory on the outskirts of Barcelona with over 100 staff; powered entirely by 100% renewable energy
- Dual ISO 22716 (one of the first certified in 2014) and ISO 13485 certifications; registered CDMO/CMO listed on CPHI
Core Expertise
- Full range of sterile single-dose formats: three single-dose delivery systems including BFS soft ampoules, glass ampoules and cosmetic syringes to align with varied brand positioning
- Complete OEM service package: custom formulation development → sterile filling → finished goods delivery, plus regulatory registration and technical documentation support
4.Phytocosma
Founded in Lyon in 1982 by a French pharmacist, Phytocosma is France’s largest manufacturer of high-concentration glass ampoule serums. Situated at the heart of France’s cosmetic industrial cluster, the company boasts over 40 years of technical expertise in ampoule filling, with full in-house control of the entire workflow from glass ampoule forming to serum filling. Its ISO 22716-certified factory handles production ranging from lab-scale trials to ton-level mass manufacturing, delivering high-concentration, preservative-free glass ampoule solutions for private label single dose skincare.
Factory Profile
- Established in 1982 with a proprietary factory in Lyon; more than 40 years of accumulated ampoule filling craftsmanship
- ISO 22716 certified; full-spectrum production capacity covering lab trials through industrial mass production
Core Expertise
- France’s top glass ampoule manufacturer: Compatible with full formula systems from low to high viscosity at high concentrations
- French botanical skincare heritage: Advanced active ingredient portfolio including peptides, plant stem cells and hyaluronic acid
5.Cosmecca Korea
Cosmecca Korea is a KOSDAQ-listed Korean cosmetic OGM (Original Global Manufacturer) founded in 1999, with manufacturing facilities in South Korea, China and the United States. Its factory in Eumseong, South Korea is equipped with mature single-dose filling lines covering two mainstream formats: BFS soft ampoules and capsule-type single-dose products, and holds CGMP and FDA OTC certifications. Cosmecca owns two patents for plant-derived PDRN from Prunus Speciosa and Dwarf Mugo Pine. It provides full-chain manufacturing capabilities for private label single dose skincare, ranging from active raw material development to filling and packaging.
Factory Profile
- Founded in 1999 with manufacturing sites across South Korea, China and the US; KOSDAQ listed (Stock Code: KQ 241710)
- Certified with CGMP, ISO 22716 and FDA OTC; holder of dual patents for plant-derived PDRN
Core Expertise
- OGM service model: One-stop full-spectrum manufacturing covering raw material innovation to single-dose filling
- Leading K-beauty trend formulations: Cutting-edge products including single-dose fermented serums and peptide complexes
6.Crevil
Crevil is a cosmetic and pharmaceutical CDMO manufacturer based in Munich, Germany, complying with both pharmaceutical GMP and cosmetic ISO 22716 standards. Its product portfolio includes drops, sprays, suspensions, creams and ointments. The manufacturer applies pharmaceutical-grade formula development and aseptic production standards directly to its private label single dose skincare manufacturing, with products distributed across Europe, North America, the Middle East, Asia and Africa.
Factory Profile
- Self-owned production site in Munich with 100–249 employees; registered CDMO/CMO listed on CPHI
- Dual certifications of GMP and DIN EN ISO 22716, capable of manufacturing multiple formulations such as drops, sprays, creams and ointments
Core Expertise
- Pharmaceutical-grade CDMO services: Full-chain support covering formula development, production, packaging and regulatory registration, plus global multi-market distribution
- German manufacturing quality: Adherence to stringent DIN EN ISO 22716 standards, operating dual business lines for private brands and contract manufacturing
7.Briemar
Founded in 1975, Briemar is a licensed Australian contract manufacturer of pharmaceutical and cosmetic sachet products holding a TGA manufacturing licence, alongside ISO 22716 and ISO 13485 certifications. Its facility in Victoria specialises in high-precision sachet filling for liquids, gels, powders and granules, delivering manufacturing services complying with Australia’s strictest safety standards for private label single dose skincare.
Factory Profile
- Established in 1975 with over 50 years of Australian manufacturing experience; TGA pharmaceutical manufacturing licensed
- Triple certifications: ISO 22716 (Cosmetic GMP), ISO 13485 (Medical Devices) and TGA accreditation
Core Expertise
- Specialist in single-dose sachets: High-precision filling for diverse formats including liquids, gels, powders and granules
- Australian-made credential: Adopts TGA pharmaceutical-grade standards for skincare contract production with rare manufacturing capacity in the Southern Hemisphere
Summary
The supplier selection logic for single-dose skincare OEM differs drastically from that of conventional skincare. While traditional skincare manufacturing focuses on formula stability and texture optimization, the core challenges of single-dose packaging lie in aseptic filling and active ingredient preservation.
When vetting single-dose manufacturers, I recommend prioritizing three key hard criteria: whether they are equipped with BFS or equivalent aseptic filling machinery, whether they maintain Class 100,000 or higher cleanroom standards, and whether they offer comprehensive regulatory compliance support for your target markets.
If you are searching for a private label single dose skincare OEM partner with global certifications, clean formula systems and professional BFS aseptic filling technology, feel free to get in touch with us.
