Choosing a professional and reliable acne treatment product manufacturer is the key for effective skincare brands to gain a foothold in the highly competitive market.
Acne treatment products involve the precise formulation of active ingredients such as salicylic acid, azelaic acid, and piroctone olamine, which demand extremely high standards for formula stability, permeability, and gentleness.This article provides an in-depth analysis of eight global manufacturers with unique expertise in the acne treatment field, helping you find the ideal partner that aligns with your brand positioning.
Capability Comparison of Acne Treatment Product Manufacturers
| Manufacturer Name | Headquarters Location | Core Strengths and Expertise | Suitable Partner Types | Key Services |
| Kolmar Korea | South Korea | Pharmaceutical-grade R&D background, high-efficacy active ingredient processing technology, specializing in potent anti-acne and oil-control formulations. | Professional skincare brands pursuing clinical-grade efficacy verification and positioned at the high-end. | Customization, Clinical Testing, Global Registration Support |
| Cosmecca Korea | South Korea | World-class biotechnology R&D capabilities, specializing in the development of probiotic-fermented anti-acne ingredients and skin microbiome regulation. | Brands focusing on cutting-edge biotechnology and pursuing differentiated anti-acne mechanisms. | Biotechnology R&D, efficacy verification, global manufacturing. |
| DESIFINE | China (Sino-German Joint Venture) | German-style rigorous R&D system, over 2000 mature formulas. Acne and post-acne repair products have passed strict stability tests. | Global brands pursuing German-style quality, focusing on cost and delivery efficiency. | Full-range OEM/ODM, formula R&D, efficacy verification. |
| Intercos | Italy | World-class sensory experience design, integrating acne-fighting active ingredients with luxurious textures, specializing in high-end anti-acne serums and ampoules. | Brands positioned at the high-end, pursuing artistic product design and a sense of ritual in usage. | Deep customization, luxury formula development, brand consulting. |
| Fareva | France | One of the largest cosmetic contract manufacturers in Europe, with large-scale production capacity and a strict quality control system. | Established brands planning for large-scale production and in need of a stable supply chain. | Large-scale OEM/ODM, GMP production, global supply. |
| COSMAX | South Korea | A global ODM giant with rapid response to market trends, boasting a large acne-treatment formula library and active ingredient research database. | Brands that require rapid time-to-market, large-scale production, and cost control. | Full-category ODM, trend analysis, global supply chain. |
| Hankook Cosmetics | South Korea | A well-known cosmetics manufacturer from South Korea with over 70 years of history, boasting profound experience in the field of functional skincare products. | Brands pursuing the quality of Made in Korea and requiring stable production guarantees. | OEM/ODM, formula development, stable production |
| NEFTIS LABORATORIOS | Spain | Professional OEM manufacturer based in Barcelona, covering a full range of categories from cosmetics to medical devices, specializing in chemical peels and acne treatment products. | Brands pursuing professional European manufacturing and in need of diversified product line development. | Formula Development, Medical Device Manufacturing, Customized Production |
1.Kolmar Korea
Kolmar Korea is a world-leading cosmetics ODM company. Its predecessor was Korea’s first professional pharmaceutical company.With a profound pharmaceutical background, it integrates the rigor of pharmaceutical R&D into acne treatment product development, and has established an authoritative position in high-efficacy active ingredient processing technology. It is a trusted acne treatment product manufacturer for brands pursuing clinical-grade efficacy.
- Founded: 1990 (spun off from Kolmar Pharmaceuticals)
- Location: Seoul, South Korea
- Market Positioning: ODM specialist for pharmaceutical-grade, high-end efficacious skincare products
- Price Range: High-end
Core Strengths & Expertise
Kolmar Korea’s unique advantage as an acne treatment manufacturer lies in its pharmaceutical heritage:
- Pharmaceutical-Grade R&D Standards: It applies pharmaceutical-level stability testing, safety evaluation, and efficacy verification processes to acne product development, producing highly convincing data reports.
- High-Efficacy Active Ingredient Expertise: It owns numerous patented technologies in salicylic acid encapsulation & sustained release, Pionin nanonization, azelaic acid transdermal absorption, and more.
- Multi-Pathway Acne Control System: Specializes in building multi-target formula systems that cover inhibiting Cutibacterium acnes, regulating sebum secretion, and anti-inflammatory repair.
R&D & Production Capabilities
- Strong R&D Infrastructure: It has over 1,100 R&D personnel worldwide and develops more than 8,000 new products annually.
- Global Supply Chain Network: Production bases in South Korea, China, the U.S., Indonesia and other locations support brands’ global expansion.
- Comprehensive Compliance Support: Familiar with acne product claim regulations in major global markets, providing professional registration and filing services.
Summary
Kolmar Korea is an ideal partner for brands pursuing clinical-grade efficacy verification and aiming to position themselves as professional cosmeceuticals.It has a relatively high cooperation threshold, making it more suitable for medium-to-large brands with clear market positioning and sufficient budgets.
2. Cosmecca Korea
Cosmecca Korea is one of the world’s leading cosmetics ODM companies, renowned in the industry for its outstanding biotechnology R&D capabilities. As an innovation-driven acne treatment product manufacturer, it focuses on applying biotechnological achievements to the acne care sector, and has established unique technological barriers especially in probiotic fermented ingredients and skin microbiome regulation.
- Founded: 1999
- Location: South Korea
- Market Positioning: Global cosmetics ODM specialist driven by biotechnology
- Price Range: Mid-to-high-end
Core Strengths & Expertise
As an acne treatment product manufacturer, Cosmecca Korea’s core competitiveness lies in its strong biotechnology R&D capabilities:
- Fermentation Technology Expertise: Possesses a world-class microbial fermentation R&D platform, capable of developing proprietary fermented acne‑fighting active ingredients with independent intellectual property rights.
- Skin Microbiome Research: Focuses on improving acne conditions by regulating skin microflora balance, and has developed innovative anti-acne formulas based on postbiotics and prebiotics.
- Global R&D Network: Has R&D centers in South Korea, China, the United States and other regions, integrating cutting-edge global scientific resources.
R&D and Production Capabilities
- Strong Patent Portfolio: Owns numerous international patents in biological fermentation, active ingredient extraction and other fields.
- Efficacy Verification System: Equipped with a complete in vitro and clinical efficacy testing platform, which can provide scientific data support for acne treatment claims.
- Globalized Production: Has production bases in many regions around the world, supporting the international development of brands.
Summary
Cosmecca Korea is an ideal partner for brands aiming to integrate cutting-edge concepts such as biotechnology and skin microbiome into acne products, and create differentiated efficacy selling points.
3.DESIFINE
DESIFINE is a Sino‑German joint venture acne treatment product manufacturer that successfully combines Germany’s rigorous R&D system with China’s supply chain efficiency. Led by Dr. ROLF LENTFER, a senior German technical consultant with over 50 years of industry experience, DESIFINE has established strict full‑chain standards for acne care products, from raw material selection to finished product delivery. Products undergo 3–6 months of stability testing, with heat‑cold resistance ranging from -8°C to 55°C, far exceeding conventional industry standards.
- Founded: 2000
- Location: China (Sino‑German joint venture, German chief technical advisor)
- Market Positioning: OEM/ODM manufacturer of efficacious skincare products under German management standards
- Price Range: Mid-to-high end, balancing quality and cost-effectiveness
Core Strengths & Expertise
As an acne treatment product manufacturer, DESIFINE’s core competitiveness lies in its quality‑first German heritage:
- Led by a German Chief Technical Advisor: Dr. ROLF has 51 years of experience in the international cosmetics industry, and his core anti‑acne formulas have been fully integrated into DESIFINE’s R&D system.
- Testing Exceeding Industry Standards: Anti‑acne products undergo formula improvement testing for no less than 3 months, with cold resistance down to -20°C, ensuring the stability of active ingredients under various climatic conditions.
- Expertise in Natural Botanical Anti-Acne Solutions: Specializes in the scientific combination of anti-acne botanical extracts (such as sophora root, salvia miltiorrhiza root, wild chrysanthemum, and licorice root) with modern anti-acne ingredients.
R&D and Production Capabilities
- Strong R&D Capability: Over 2,000 mature and stable formulas, more than 30 patent applications in total. Since 2022, DESIFINE has cooperated with South China University of Technology and Guangzhou University of Chinese Medicine on formula R&D.
- Modern Production Base: Covers 15,000 square meters, with a USD 7 million investment in high‑end production and testing equipment imported from France, Germany, and Switzerland.
- Independent Quality Control Authority: The quality department is fully independent; microbial standards exceed national requirements, allergens are screened in accordance with EU standards, and the product qualification rate remains above 99%.
- Partner Network: Cooperative brands include Douglas, Walgreens Boots Alliance, Watsons, MINISO, and other internationally renowned enterprises.
Summary
DESIFINE is an ideal technical partner for brands seeking rigorous German quality, focusing on the stability and safety of anti-acne products, while valuing the efficiency of the Asian supply chain. Its testing system, which exceeds industry standards, provides a solid guarantee for the efficacy and safety of anti-acne products.
4. Intercos
Intercos Group is a world-leading manufacturer of color cosmetics and skincare products, renowned for seamlessly integrating artistic creativity with precision technology. As an acne treatment product manufacturer, it specializes in incorporating acne‑fighting active ingredients into luxurious‑texture formulations, providing end‑to‑end solutions from concept to finished product for brands pursuing a high‑end positioning.
- Founded: 1972
- Location: Milan, Italy
- Market Positioning: Global leader in high‑end beauty solutions
- Price Range: High‑end
Core Strengths & Expertise
As an acne treatment product manufacturer, Intercos’ unique value lies in the integration of art and technology:
- Superior Sensory Experience: It places strong emphasis on the texture, absorption, and post-application skin feel of acne serums and ampoules, breaking the stereotype that “effective products have poor texture.”
- Unique Packaging Integration: It combines distinctive packaging designs (such as patented containers and innovative dosage forms) with high-efficiency formula technology to create impressive product experiences.
- High-End Market Credibility: It serves many top international luxury brands, and its cooperation track record is a guarantee of quality and credibility.
R&D and Production Capabilities
- Global Creative Network: It has creative research centers in many locations around the world, integrating aesthetic preferences from different markets.
- In-Depth Customization Services: It can transform brand stories into unique product forms and sensory experiences.
- Extreme Attention to Detail: It pursues the highest standards in raw material quality, packaging craftsmanship, and finished product appearance.
Summary
Intercos is the ideal partner for brands aiming to elevate acne products to luxury skincare level and pursue differentiated product experiences.Its cooperation threshold and cost are relatively high accordingly.
5. Fareva
Fareva is one of the largest cosmetic contract manufacturers in Europe, with more than 40 production facilities worldwide. As a large-scale acne treatment product manufacturer, it provides stable, efficient, large-scale production services for well-known international cosmeceutical and mass-market brands.
- Location: France (with factories in many countries globally)
- Market Positioning: Large-scale, multi-category contract manufacturer
- Price Range: Mid to high-end, depending on project scale
Core Strengths & Expertise
As an acne treatment product manufacturer, Fareva’s core advantages lie in its economies of scale and production stability:
- Ultra-large-scale Production Capacity: Capable of handling acne product orders ranging from 1 million to 10 million units, ensuring absolute stability of the supply chain.
- Pharmaceutical-grade Quality Standards: It applies the quality management system from pharmaceutical production to cosmetics manufacturing, guaranteeing the safety and consistency of each batch.
- Multi-category Synergy: In addition to acne care products, it can also produce supporting products such as cleansers and masks, simplifying supply chain management.
R&D and Production Capabilities
- Global Layout: Production bases across Europe, Americas, Asia and other regions support brands’ global supply strategies.
- Strict Quality Control: Holds many international certifications including ISO 22716 and GMP.
- Cost Advantage: Provides brands with a highly competitive cost structure through large-scale procurement and production.
Summary
Fareva is an ideal partner for established brands planning large‑scale market launches and requiring stable supply chain support.Its scale advantages may not be fully realized for start‑up brands or small‑batch customized orders.
6. COSMAX
COSMAX is one of the world’s largest cosmetics ODM companies, renowned for its remarkable R&D speed, extensive formula library, and sharp market insight. As an acne treatment product manufacturer, it possesses a massive database of anti-acne formulas and the ability to rapidly integrate emerging anti-acne ingredients.
- Founded: 1992
- Location: Seoul, South Korea (with R&D centers and production bases worldwide)
- Market Positioning: Global leading full-category cosmetics ODM solution provider
- Price Range: Mid-end to high-end
Core Strengths & Expertise
As an acne treatment product manufacturer, COSMAX’s core strength lies in its trend‑converting capability:
- Rapid Trend Response: With a strong market analysis team, it can quickly turn trending anti‑acne ingredients on social media (such as azelaic acid, pionin, bakuchiol, etc.) into scalable formulations.
- Extensive Formula Database: It has thousands of market‑proven anti‑acne formulas covering all needs from mild comedones to severe acne.
- Cutting‑Edge Technology Application: It continues to invest in AI‑assisted formula development, skin microbiome research and other advanced fields, providing technical reserves for acne product innovation.
R&D and Production Capabilities
- Global R&D Network: R&D centers in South Korea, China, the United States, Indonesia and other regions integrate global scientific research resources.
- One‑Stop Service: Provides full‑chain support from market insight, product planning, formula R&D to industrial design, production and logistics.
- Flexible Production Scale: Supports all needs from small‑batch trial production to large‑scale mass production.
Summary
COSMAX is an ideal partner for brands pursuing fast time‑to‑market and needing to closely follow acne market trends.Its huge formula library can greatly shorten the new product development cycle.
7. Hankook Cosmetics
Hankook Cosmetics is one of South Korea’s oldest cosmetics manufacturers with over 70 years of industry experience. As an acne treatment product manufacturer deeply rooted in functional skincare, it has built strong expertise in stable production, formula accumulation, and supply chain management.
- Founded: 1947
- Location: South Korea
- Market Positioning: Long-established South Korean OEM/ODM manufacturer of functional skincare products
- Price Range: Mid-end
Core Strengths & Expertise
As an acne treatment product manufacturer, Hankook Cosmetics’ core strengths lie in its profound historical heritage:
- Rich Formula Experience: With more than 70 years of industry development, it has accumulated a large number of market-proven classic anti-acne formulas.
- Stable Production System: It has mature production management and quality control processes to ensure stable and reliable bulk product quality.
- Supply Chain Integration Capability: It has established long-term partnerships with high-quality raw material suppliers worldwide, guaranteeing raw material quality.
R&D and Production Capabilities
- Modern R&D Facilities: Equipped with advanced R&D equipment and a professional R&D team, it continues to carry out formula innovation.
- Flexible Production Scale: Able to accommodate various production demands from small and medium batches to large-scale production.
- Quality Traceability: A complete quality traceability system has been established, allowing every batch of products to be traced back to the source of raw materials.
Summary
Hankook Cosmetics is a practical choice for brands seeking stable and reliable production, valuing Korean-made quality, and wanting support from mature formulas.
8. NEFTIS LABORATORIOS
NEFTIS LABORATORIOS, based in Barcelona, Spain, is a professional OEM contract manufacturer specializing in cosmetics, medical devices, dermatological treatment products, and other fields. As a European-style acne treatment product manufacturer, they offer a full range of services from standard formulas to fully customized products, and have accumulated extensive experience especially in chemical peels and acne treatment products.
- Location: Barcelona, Spain
- Market Positioning: OEM contract manufacturer for cosmetics and medical devices, focusing on the professional dermatology market
- Price Range: Mid-to-high-end
Core Strengths & Expertise
As an acne treatment product manufacturer, the unique value of NEFTIS LABORATORIOS lies in its diversified product portfolio and professional channel experience:
- Full-Category Manufacturing Capability: Covers a wide range of categories including cosmetics, medical devices (from Class I chemical peels to Class III sterile injectables), nutritional supplements, and hygiene products, providing rich technical reserves for acne product development.
- Expertise in Chemical Peels: In the field of acne treatment, it specializes in developing chemical peel products, offering highly effective acne solutions for professional beauty institutions and dermatologists.
- Customized R&D Services: The R&D department provides both pre-formulated and tested standard formulas and fully customized products based on client requirements, satisfying the differentiated positioning of various brands.
R&D and Production Capabilities
- European Professional Market Experience: Deeply rooted in the international and Spanish local professional beauty market, it understands the professional demands of dermatologists and aesthetic professionals for acne products.
- Application of Cutting-Edge Technologies: Committed to applying the latest technologies to deliver the highest-quality products and services to the market.
- Diversified Product Portfolio: Capable of supporting brands in developing a complete acne product matrix from professional lines to daily skincare lines.
Summary
NEFTIS LABORATORIOS is an ideal partner for brands aiming to integrate European professional cosmeceutical concepts into acne products and build doctor-recommended or professional salon brands. Its expertise in chemical peels and medical device manufacturing creates a unique technological moat for acne product lines.
Summary
By now, we believe you have gained a clear understanding of these eight distinctive global acne treatment product manufacturers and have formed initial ideas for potential partnership directions.
From pharmaceutical-grade R&D at Kolmar Korea, to biotechnology-driven Cosmecca Korea; from German precision combined with Asian insights at DESIFINE, to luxurious sensory experiences at Intercos; from large-scale manufacturing at Fareva, to fast trend-responsive COSMAX; to long-established Korean expert Hankook Cosmetics and Spanish professional cosmeceutical specialist NEFTIS LABORATORIOS — each path leads to a unique brand future.
Choosing the right partner is only the first step toward building a successful product.
If you are planning your own acne skincare brand and aim to turn professional R&D, stable quality, and a reliable supply chain into unique competitive advantages in the market, we are ready to support you.
Should you wish to create your own professional acne skincare brand, please feel free to contact us anytime.
